Gutkind Lab

Translating our scientific discoveries into novel precision treatment options and immunotherapies to prevent and treat cancer.


G proteins/GPCRs and Cancer

GPCRs, the largest family of cell-surface molecules involved in signal transmission, have recently emerged as crucial players in tumour growth and metastasis.

HNSCC / Oral Cancer / PI3K-mTOR

The PI3K/mTOR signaling pathway is one of the most frequently dysregulated molecular mechanisms in HNSCC. mTOR inhibition halts tumor progression.

Immune Oncology

Recent revolutionary therapeutic strategies restoring T cell mediated anti-tumor immunity by immune modulating agents have achieved remarkable clinical responses including in HNSCC.

Uveal Melanoma

Around 90% of ocular melanomas harbor gain-of- function mutations in GNAQ or GNA11, where they are now consideretd to represent the driver oncogenes.


November 13, 2023

UC San Diego Health Sciences News

J. Silvio Gutkind, PhD, Received American Cancer Society (ACS) Research Professor Award

The nation’s largest non-government, non-profit funder of cancer researcher, ACS, has awarded Moores Member, J. Silvio Gutkind, Ph.D., the ACS Research Professor Award.

Dr. Gutkind is one of two recipients of this prestigious award for investigators who have made ground-breaking contributions in cancer research. This award recognizes exceptional track records in leadership, service, and mentoring in cancer research.

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October 6, 2020

UC San Diego Health Sciences News

J. Silvio Gutkind, PhD, Named Chair of the Department of Pharmacology

J. Silvio Gutkind, PhD, has been named chair of the Department of Pharmacology at University of California San Diego School of Medicine.

Gutkind joined the UC San Diego School of Medicine faculty in 2015 and has served as Distinguished Professor in the Department of Pharmacology, as well as associate director of basic science and co-director of the Head and Neck Cancer Center at Moores Cancer Center.

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October 19, 2019

UC San Diego Health Sciences News

UC San Diego Moores Cancer Center's J. Silvio Gutkind Joins National Academy of Medicine

Considered one of the highest honors in the fields of health and medicine, J. Silvio Gutkind, PhD, Distinguished Professor of Pharmacology at University of California San Diego School of Medicine and associate director for basic science at Moores Cancer Center, has been elected to the National Academy of Medicine (NAM).

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