Gutkind Lab

Translating our scientific discoveries into novel precision treatment options and immunotherapies to prevent and treat cancer.


G proteins/GPCRs and Cancer

GPCRs, the largest family of cell-surface molecules involved in signal transmission, have recently emerged as crucial players in tumour growth and metastasis.

HNSCC / Oral Cancer / PI3K-mTOR

The PI3K/mTOR signaling pathway is one of the most frequently dysregulated molecular mechanisms in HNSCC. mTOR inhibition halts tumor progression.

Immune Oncology

Recent revolutionary therapeutic strategies restoring T cell mediated anti-tumor immunity by immune modulating agents have achieved remarkable clinical responses including in HNSCC.

Uveal Melanoma

Around 90% of ocular melanomas harbor gain-of-function mutations in GNAQ or GNA11, where they are now considered to represent the driver oncogenes.


October 21, 2019

UC San Diego Health Sciences News

UC San Diego Moores Cancer Center’s J. Silvio Gutkind Joins National Academy of Medicine

Considered one of the highest honors in the fields of health and medicine, J. Silvio Gutkind, PhD, Distinguished Professor of Pharmacology at University of California San Diego School of Medicine and associate director for basic science at Moores Cancer Center, has been elected to the National Academy of Medicine (NAM).

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January 13, 2020

UC San Diego Health Sciences News

How Marijuana Accelerates Growth of HPV-related Head and Neck Cancer Identified

University of California San Diego School of Medicine researchers have identified the molecular mechanism activated by the presence of tetrahydrocannabinol (THC) — the ingredient that causes people to feel the euphoria or “high” associated with cannabis — in the bloodstream that accelerates cancer growth in patients with human papillomavirus (HPV)-positive head and neck squamous cell carcinoma.

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The Team

  • Lab celebration dinner for Silvio's election to the National Academy of Medicine
  • The traditional Gutkind Lab team jump at the 2019 Moores Cancer Center Delivering Discoveries Scientific Retreat
  • Our annual lab party!
  • Lab members participating in Pedal for a Cause, November 2019
  • Lab photo on the patio of the Moores Cancer Center.
  • Wishing lab member Mara a fond farewell!